/u/Adernain's posts in /r/askscience

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During clinical trials of any vaccine, is there an acceptable adverse events rate that needs to be passed in order to fail the trial? How do you judge that?

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What is the deal with CFR/IFR of COVID-19? Does it take years to get an accurate one? So far it has been measured to be around 0,5-5% but there are articles claiming to be a bit lower.

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If a vaccine for COVID-19 rolls out early, how do we know it won't have any long-term adverse effects? Are the effects only short-term because it mimics the virus?

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If someone dies for example from a heart attack and was also positive to COVID-19, will the death be attributed to both causes or only one of them?

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Is it true that if we perform mass PCR-testing we get more false positives and -negatives? If yes, what causes this?

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I've seen claims, including from doctors, saying that the more PCR-tests you do to test a population, you might get up to 50% false positive results. Is this true, or at least partially? If yes what leads to this effect?

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If a cancer patient catches an infection, like the common flu, and dies from it, would cancer be the cause of death, just like when an AIDS patient that catches an opportunistic infection dies from AIDS?

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Does the time length of a clinical trial affect the efficacy of a trialed vaccine?

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Title	Upvotes	Mark as read	Favorited	Rating	Add to a list
During clinical trials of any vaccine, is there an acceptable adverse events rate that needs to be passed in order to fail the trial? How do you judge that?	1
What is the deal with CFR/IFR of COVID-19? Does it take years to get an accurate one? So far it has been measured to be around 0,5-5% but there are articles claiming to be a bit lower.	1
If a vaccine for COVID-19 rolls out early, how do we know it won't have any long-term adverse effects? Are the effects only short-term because it mimics the virus?	1
If someone dies for example from a heart attack and was also positive to COVID-19, will the death be attributed to both causes or only one of them?	1
Is it true that if we perform mass PCR-testing we get more false positives and -negatives? If yes, what causes this?	1
I've seen claims, including from doctors, saying that the more PCR-tests you do to test a population, you might get up to 50% false positive results. Is this true, or at least partially? If yes what leads to this effect?	1
If a cancer patient catches an infection, like the common flu, and dies from it, would cancer be the cause of death, just like when an AIDS patient that catches an opportunistic infection dies from AIDS?	1
Does the time length of a clinical trial affect the efficacy of a trialed vaccine?	1