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Why are medical trials needed for the use of medicine to treat Covid-19 for medicines that are already approved by the FDA for the treatment of other deseases (such as Ivermectin for intestinal worms)?

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Why are medical trials needed for the use of medicine to treat Covid-19 for medicines that are already approved by the FDA for the treatment of other deseases (such as Ivermectin for intestinal worms)?	1
Excercise: Why do some muscles or type of excercises give a burning sensation (like leg extension or abs) while most others tipically just reach failure?	1