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How can statistics tell the current Corona reproduction number accurately (e. g. RKI in Germany) when they know neither the number of infected people now nor at any time in the past?

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How can statistics tell the current Corona reproduction number accurately (e. g. RKI in Germany) when they know neither the number of infected people now nor at any time in the past?	2
After 3 shots Comirnaty / Spikevax, how many shots of an upcoming, Omicron-specific vaccine will we need?	1