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One of the primary reasons many native groups in the Americas were largely wiped out were diseases to which they had no natural defences against. However I was wondering if the contrary ever happened, like were there diseases found in the new world that were new to settlers?

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One of the primary reasons many native groups in the Americas were largely wiped out were diseases to which they had no natural defences against. However I was wondering if the contrary ever happened, like were there diseases found in the new world that were new to settlers?	154