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The brain is able to adjust to heightened levels of neurotransmitters(when taking drugs for example) by changing the number of receptors, but how does the brain know to do this?

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The brain is able to adjust to heightened levels of neurotransmitters(when taking drugs for example) by changing the number of receptors, but how does the brain know to do this?	1
To what extent is public opinion influenced by media and to what extent is media influenced by public opinion?	1