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When you take medicine (a pill in this example) and immediately go to sleep, does it enter your system and work the same and as quickly as if you were awake?

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When you take medicine (a pill in this example) and immediately go to sleep, does it enter your system and work the same and as quickly as if you were awake?	1
A question about genetics related to game of thrones so there's possibly a spoiler in the question.	1